The Different Essential Aspects Of The Research Study
Article analysis is an essential aspect of understanding the different parts of the research article. It helps point out the different essential aspects of the research study. This discussion identifies the research problem/hypotheses, purpose statement, study design, participants and how they were selected, the results, whether the hypothesis was rejected or accepted, and the study limitations of a selected article. The selected study is “High-dose vitamin D substitution in patients with COVID-19: study protocol for a randomized, double-blind, placebo-controlled, multi-center study—VitCoy Trial” by Jaun et al. (2022)The Different Essential Aspects Of The Research Study.
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The research problem is that there is uncertainty about the direct link between vitamin D deficiency and the severity of Cvid-19, despite evidence supporting an association between vitamin D deficiency and Covid-19 severity. The study’s purpose statement is; to assess whether high-dose vitamin D supplementation has a therapeutic effect in vitamin D-deficient patients with Covid-19. The Different Essential Aspects Of The Research Study
The study design is a randomized, placebo-controlled, double-blind, multi-center approach was chosen to compare a high single dose of vitamin D (140,000 IU) followed by treatment as usual (TAU) (VitD + TAU) with treatment as usual only (placebo + TAU) in patients with COVID-19 and vitamin D deficiency. The participants were individuals hospitalized in a general medicine ward due to Covid-19. They were selected based on laboratory-confirmed vitamin D deficiency. The Different Essential Aspects Of The Research Study
The intervention group entails the participants that will receive a single oral dose of 140,000 IU of vitamin D3, then continue with the standard oral dose of 800 IU of vitamin D3 daily until discharge. The control group entails the participants who will receive a single placebo orally and then continue with the standard oral dose of 800 IU of vitamin D3 daily. The outcomes measured are the differences between the TAU+VitD and TAU+placebo in terms of ICU stay, overall mortality, vitamin D serum concentration, laboratory parameters, sepsis, complications, vital signs, and quality of life. The article does not have the results since it is a study protocol/trial that will be implemented later. The Different Essential Aspects Of The Research Study
Finally, the study limitations include travel regulations and other policies which may be unpredictable, following the unpredictable situations of Covid-19, limiting access to patients. Additionally, due to public health policies, the study implementation may be limited by reducing the number of hospitalized patients.
References
Jaun, F., Boesing, M., Lüthi-Corridori, G., Abig, K., Makhdoomi, A., Bloch, N., Lins, C., Raess, A., Grillmayr, V., Haas, P., Schuetz, P., Gabutti, L., Muser, J., Leuppi-Taegtmeyer, A. B., Giezendanner, S., Brändle, M., & Leuppi, J. D. (2022). Trials, 23(1), 1–11 https://doi.org/10.1186/s13063-022-06016-2 The Different Essential Aspects Of The Research Study
