Effects of Olanzapine Combined With Samidorphan On Weight Gain in Schizophrenia Essay
You are to find aa peer reviewed scholarly article (from a journal of nursing, is preferred) and write a summary of that article. You need to read the whole article and summarize the article in your own words. Please include the following
Title Page
Thesis Statement
Include 250 word in the body of the paper
References page
Attach the entire article with your submission, not just the the abstract or summary of the article.
You need to follow APA 7, no extra spaces between paragraphs, do not justify the margins! Everything is only left justified, with References having the DOI or web address.
Remember, this is your summary of the article.
According to Polit and Beck, an article review contains the following in sentences (not bullet points).
Start with a summary or overview of the article which includes the author’s name and the title of the article.
Your summary should be about one third of the length of the original article. Your summary should include: Introduction
State the main ideas of the article.
Identify the most important details that support the main ideas.
Write your summary in your own words; avoid copying phrases and sentences from the article unless they’re direct quotations.
Express the underlying meaning of the article, not just the superficial details.
***The article and references must be within last 5 years*** Effects of Olanzapine Combined With Samidorphan On Weight Gain in Schizophrenia Essay
Summary of the article “Effects of Olanzapine Combined With Samidorphan On Weight Gain in Schizophrenia: A 24-week Phase 3 Study.”
Correll, C. U., Newcomer, J. W., Silverman, B., DiPetrillo, L., Graham, C., Jiang, Y., Du, Y., Simmons, A., Hopkinson, C., McDonnell, D., & Kahn, R. S. (2020). Effects of olanzapine combined with samidorphan on weight gain in schizophrenia: A 24-week phase 3 study. The American Journal of Psychiatry, 177(12), 1168–1178. https://doi.org/10.1176/appi.ajp.2020.19121279
Correll et al. (2020) investigate the relationship between olanzapine and weight gain in rats. The experimental model of olanzapine-induced weight gain shows that olanzapine brings about features like excessive hunger, hyperleptinemia, insulin resistance, and weight gain attenuation by topiramate (Kao et al., 2018). For the management of psychosis illness, a combination of olanzapine and an opioid receptor antagonist, samidorphan, is being developed. The single-tablet combo therapy is designed to give olanzapine effectiveness while reducing olanzapine-related weight gain. This paper aims to summarize the research article on the effectiveness of combining olanzapine and samidorphan to arrest olanzapine-induced weight gain.
The study showed that the participants who took olanzapine as a single therapy versus those who took it in combination with samidorphan had a significant weight reduction in the ones who had combined therapy. At the end of the research, the combined olanzapine and samidorphan group gained a total of 3.1 kg, whereas the olanzapine group gained five kilos (Correll et al., 2020). The precise mechanism of action of olanzapine and samidorphan combination is unclear, with preclinical animal experimental data implying that olanzapine causes weight and metabolic abnormalities and that samidorphan reduces olanzapine-associated variations in fat accumulation via inhibiting adipose glucose absorption and reducing olanzapine-induced insulin resistance. The outcomes emerged in the absence of higher food intake or changing eating patterns, which is significant. However, this is still an active study topic since many elements of the mechanism of action of the combination of olanzapine and samidorphan are unknown.
The article concludes by proving that the combination of olanzapine and samidorphan was demonstrated to minimize the significant adverse effect of olanzapine-associated weight gain while retaining olanzapine’s proven antipsychotic effectiveness. As a result, individuals may benefit from a novel therapy option that combines olanzapine and samidorphan (Correll et al., 2020). Effects of Olanzapine Combined With Samidorphan On Weight Gain in Schizophrenia Essay
References
Correll, C. U., Newcomer, J. W., Silverman, B., DiPetrillo, L., Graham, C., Jiang, Y., Du, Y., Simmons, A., Hopkinson, C., McDonnell, D., & Kahn, R. S. (2020). Effects of olanzapine combined with samidorphan on weight gain in schizophrenia: A 24-week phase 3 study. The American Journal of Psychiatry, 177(12), 1168–1178. https://doi.org/10.1176/appi.ajp.2020.19121279
Kao, A. C.-C., Spitzer, S., Anthony, D. C., Lennox, B., & Burnet, P. W. J. (2018). Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota. Translational Psychiatry, 8(1), 1–12. https://doi.org/10.1038/s41398-018-0116-8 Effects of Olanzapine Combined With Samidorphan On Weight Gain in Schizophrenia Essay
